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Ulbrich Karel

Prof., Ing., DrSc.
Born February 27, 1947 in Prague, † 2019 

  • Macromolecular chemistry, biomedical polymers
  • Member of Learned Society since 2003

Educational and professional preparation

  • 1965, graduate, Parléř academic secondary school, Prague 6;
  • 1965-1970, Institute of Chemical Technology (ICT), Prague;
  • 1975, CSc., in macromolecular chemistry, Institute of Macromolecular Chemistry, Czechoslovak Academy of Sciences (IMC CSAS);
  • 2000, Associate Professor in macromolecular chemistry, ICT;
  • 2001, DrSc., IMC, Academy of Sciences of Czech Republic (AS CR).
  • 2005, Professor in macromolecular chemistry, ICT;

Employment and academic positions

  • 1971-1975, post-graduate student, IMC CSAS;
  • 1975-present, scientist at IMC, CS AS (later AS CR);
  • 1988-present, Head, Department of Biomedical Polymers, IMC, AS CR;
  • 1994-1998, Deputy Director, IMC, AS CR,
  • 1998-2007, Director of IMC AS CR;
  • 1992-present, adjunct associate professor, University of Utah (USA)

Membership in selected domestic scientific bodies

  • 2002-present, member Scientific Council, Tomáš Baťa University, Zlín;
  • 2003-present, member, Scientific Council, ICT;
  • 2008-present, member, Scientific Council, 1st Faculty of Medicine, Charles University, Prague;
  • 2009-present, member, Scientific Council, Faculty of Natural Sciences, Charles University, Prague;
  • 1999-present, member, Scientific Council, Polymer Institute, Slovak Academy of Sciences;
  • 1994-present, member, Scientific Council, Faculty of Chemical Technology of ICT;
  • 2003 present, Chairman, Commission for Granting the Title of Doctor of Science in Macromolecular Chemistry, AS CR;
  • 2009-present, chairman, Gremium for conferring the D.Sc. degree, AS CR;
  • 2007-present, member, Council of the Institute of Macromolecular Chemistry, AS CR;
  • 2007-present, member, Council of the Institute of Chemical Processes, AS CR;
  • 2007-present, member, Supervisory Board, Microbiology Institute, AS CR;
  • 2009-present, vice chairman, Scientific Board, AS CR;
  • 1991-2007; 2010-present, member, Academy Assembly, AS CR

Membership and positions in international organizations and societies

  • Member, Controlled Release Society
  • Member, International Union for Pure and Applied Chemistry (IUPAC)
  • Member, editorial boards of: J. Controlled Release, Europ. J. Pharm. Sci., J. Bioact. Biocompat.Polymers, Am. J. Drug Delivery, Central European Journal of Chemistry, J. Biomater. Sci., Polymer Edition
  • Member, international editorial advisory board of Polymer (Korea) and the journal Macromol. Biosci.
  • Member, Scientific Council, Polymer Institute, Slovak Academy of Sciences
  • 2005-present, member, Committee for conferring the Dr.Sc. degree in macromolecular chemistry and technology of macromolecular compound, Slovak Academy of Sciences;

Notable awards

  • 1996, Award, Learned Society of the Czech Republic (for work in macromolecular chemistry)
  • 2002, Award, Minister of Education, Youth and Sports (for the results of scientific work)
  • 2004, Honorary Medal of the Polymer Institute of Slovak Academy of Sciences
  • 2005, Award “Invence“, Česká hlava, Czech Republic
  • 2008, Award “Praemium Academiae 2008”, AS CR

Selected publications

  •  T. Etrych, J. Strohalm, L. Kovář, M. Kabešová, B. Říhová, K. Ulbrich, HPMA copolymer conjugates with reduced anti-CD20 antibody for cell-specific drug targeting. I. Synthesis and in vitro evaluation of binding efficacy and cytostatic activity. J. Controlled Release 140, 18-26 (2009)
  • K. Ulbrich, V. Šubr: Synthetic Polymer-Drug Conjugates for Human Therapy. Chapter 1 in Handbook of Materials for Nanomedicine. Volume 1: Materials for Nanomedicine: Organic Nanostructures (M.M. Amiji and V.P. Torchilin (eds.)), p. 5-79. Pan Stanford Publishing Pte Ltd 2010
  • R. Laga, Č. Koňák, V. Šubr, K. Ulbrich, New Hydrophilic HPMA-Based Polymers for Bioreversible Shielding of Gene Delivery Vectors. Macromol. Chem. Phys. 210, 1138-1148 (2009)
  • T. Etrych, L. Kovář, V. Šubr, A. Braunová, M. Pechar, P. Chytil, B. Říhová, K. Ulbrich, High-molecular-weight Polymers Containing Biodegradable Disulfide Bonds: Sunthesis and In Vitro Verification of Intracellular Degradation. J. Bioact. Compat. Polymers 25, 5-26 (2010)
  • K. Ulbrich, V. Šubr, Structural and chemical aspects of HPMA copolymers as drug carriers, Adv. Drug Delivery Rev. 62, 150-166 (2010)
  • T. Lammers, V. Šubr, K. Ulbrich, W. E. Hennink, G. Storm, F. Kiessling, Polymeric nanomedicines for image-guided drug delivery and tumor-targeted combination therapy. Nano Today 5, 197-212 (2010)
  • T. Etrych, M. Šírová, L. Starovoytova, B. Říhová, K. Ulbrich, HPMA copolymer conjugates of paclitaxel and docetaxel with pH-controlled drug release. Molecular Pharmaceutics 7, 1015-1026 (2010)
  • Říhová, B., Etrych, T., Šírová, M., Kovář, L., Hovorka, O., Kovář, M., Benda, A., Ulbrich, K., Synergistic action of doxorubicin bound to the polymeric carrier based on N-(2-hydroxypropyl)methacrylamide copolymers through amide or hydrazone bond. Molecular Pharmaceutics 7, 1027-1040 (2010)
  • R. Laga, Č. Koňák, V. Šubr, K. Ulbrich, N. Suthiwangcharoen, N. Zhongwei, Q. Wang, Chemical Conjugation of Cowpea Mosaic Viruses with Reactive HPMA-Based Polymers, J. Biomater. Sci. Polym. Ed. 21(12)1669-1685 (2010)
  • P. Chytil, T. Etrych, J. Kříž, V. Šubr, K. Ulbrich, N-(2-Hydroxypropyl)-methacrylamide-based polymer conjugates with pH-controlled activation of doxorubicin for cell-specific or passive tumour targeting. Synthesis by RAFT polymerisation and physicochemical characterisation. Europ. J. Pharm. Sci. 41, 473-482 (2010)
  • R.A. Willemsen, M. Pechar, R.C. Carlisle, E. Schooten, R. Pola, A.J. Thompson, L.W. Seymour and K. Ulbrich, Multi-component polymeric system for tumour cell-specific gene delivery using a universal bungarotoxin linker. Pharm. Res. 11 (27), 2274-2282, (2010)

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News

26.06.20

Reaction to the case of Tomáš Hudlický: Members of the Learned Society of the Czech Republic support the freedom of expression

„We believe that free exchange of ideas is a key condition for the pursuit of truth and that the honest opinions should be scrutinized, challenged or rebutted but not censored or suppressed,“ say 45 members of the Learned Society in a statement regarding the retracted opinion paper by Prof. Tomáš Hudlický.

24.06.20

The letter by Jan Konvalinka to the President and Vice-Chancellor of the Brock University regarding the retracted article of Prof. Tomáš Hudlický

Opinions could and should be challenged, questioned or refuted but never silenced. In order to be able to think, we have to have the right to inquire, question and even offend or be mistaken,” writes Assoc. Prof. Jan Konvalinka, a biochemist at the IOCB Prague and the Vice-Rector of the Charles University, to Gervan Fearon.

27.11.19

Prof Miroslav Bárta receives the Česká hlava National Government Award

Learned Society member, Prof. Mgr. Miroslav Bárta, Dr. (Charles University Faculty of Arts) received the Česká hlava (Czech Head) National Government Award on 25 November 2019. A renowned Czech Egyptologist and archaeologist, Professor Bárta researches the history of ancient civilisations, the human relationship to the natural environment, and also for many years the evolution of complex societies. He leads the Czech Institute of Egyptology for archaeological and environmental research in Egypt and Sudan. His principal research interest is the period of the pyramid builders of the Old Kingdom.