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Ulbrich Karel

Prof., Ing., DrSc.
Born February 27, 1947 in Prague, † 2019 

  • Macromolecular chemistry, biomedical polymers
  • Member of Learned Society since 2003

Educational and professional preparation

  • 1965, graduate, Parléř academic secondary school, Prague 6;
  • 1965-1970, Institute of Chemical Technology (ICT), Prague;
  • 1975, CSc., in macromolecular chemistry, Institute of Macromolecular Chemistry, Czechoslovak Academy of Sciences (IMC CSAS);
  • 2000, Associate Professor in macromolecular chemistry, ICT;
  • 2001, DrSc., IMC, Academy of Sciences of Czech Republic (AS CR).
  • 2005, Professor in macromolecular chemistry, ICT;

Employment and academic positions

  • 1971-1975, post-graduate student, IMC CSAS;
  • 1975-present, scientist at IMC, CS AS (later AS CR);
  • 1988-present, Head, Department of Biomedical Polymers, IMC, AS CR;
  • 1994-1998, Deputy Director, IMC, AS CR,
  • 1998-2007, Director of IMC AS CR;
  • 1992-present, adjunct associate professor, University of Utah (USA)

Membership in selected domestic scientific bodies

  • 2002-present, member Scientific Council, Tomáš Baťa University, Zlín;
  • 2003-present, member, Scientific Council, ICT;
  • 2008-present, member, Scientific Council, 1st Faculty of Medicine, Charles University, Prague;
  • 2009-present, member, Scientific Council, Faculty of Natural Sciences, Charles University, Prague;
  • 1999-present, member, Scientific Council, Polymer Institute, Slovak Academy of Sciences;
  • 1994-present, member, Scientific Council, Faculty of Chemical Technology of ICT;
  • 2003 present, Chairman, Commission for Granting the Title of Doctor of Science in Macromolecular Chemistry, AS CR;
  • 2009-present, chairman, Gremium for conferring the D.Sc. degree, AS CR;
  • 2007-present, member, Council of the Institute of Macromolecular Chemistry, AS CR;
  • 2007-present, member, Council of the Institute of Chemical Processes, AS CR;
  • 2007-present, member, Supervisory Board, Microbiology Institute, AS CR;
  • 2009-present, vice chairman, Scientific Board, AS CR;
  • 1991-2007; 2010-present, member, Academy Assembly, AS CR

Membership and positions in international organizations and societies

  • Member, Controlled Release Society
  • Member, International Union for Pure and Applied Chemistry (IUPAC)
  • Member, editorial boards of: J. Controlled Release, Europ. J. Pharm. Sci., J. Bioact. Biocompat.Polymers, Am. J. Drug Delivery, Central European Journal of Chemistry, J. Biomater. Sci., Polymer Edition
  • Member, international editorial advisory board of Polymer (Korea) and the journal Macromol. Biosci.
  • Member, Scientific Council, Polymer Institute, Slovak Academy of Sciences
  • 2005-present, member, Committee for conferring the Dr.Sc. degree in macromolecular chemistry and technology of macromolecular compound, Slovak Academy of Sciences;

Notable awards

  • 1996, Award, Learned Society of the Czech Republic (for work in macromolecular chemistry)
  • 2002, Award, Minister of Education, Youth and Sports (for the results of scientific work)
  • 2004, Honorary Medal of the Polymer Institute of Slovak Academy of Sciences
  • 2005, Award “Invence“, Česká hlava, Czech Republic
  • 2008, Award “Praemium Academiae 2008”, AS CR

Selected publications

  •  T. Etrych, J. Strohalm, L. Kovář, M. Kabešová, B. Říhová, K. Ulbrich, HPMA copolymer conjugates with reduced anti-CD20 antibody for cell-specific drug targeting. I. Synthesis and in vitro evaluation of binding efficacy and cytostatic activity. J. Controlled Release 140, 18-26 (2009)
  • K. Ulbrich, V. Šubr: Synthetic Polymer-Drug Conjugates for Human Therapy. Chapter 1 in Handbook of Materials for Nanomedicine. Volume 1: Materials for Nanomedicine: Organic Nanostructures (M.M. Amiji and V.P. Torchilin (eds.)), p. 5-79. Pan Stanford Publishing Pte Ltd 2010
  • R. Laga, Č. Koňák, V. Šubr, K. Ulbrich, New Hydrophilic HPMA-Based Polymers for Bioreversible Shielding of Gene Delivery Vectors. Macromol. Chem. Phys. 210, 1138-1148 (2009)
  • T. Etrych, L. Kovář, V. Šubr, A. Braunová, M. Pechar, P. Chytil, B. Říhová, K. Ulbrich, High-molecular-weight Polymers Containing Biodegradable Disulfide Bonds: Sunthesis and In Vitro Verification of Intracellular Degradation. J. Bioact. Compat. Polymers 25, 5-26 (2010)
  • K. Ulbrich, V. Šubr, Structural and chemical aspects of HPMA copolymers as drug carriers, Adv. Drug Delivery Rev. 62, 150-166 (2010)
  • T. Lammers, V. Šubr, K. Ulbrich, W. E. Hennink, G. Storm, F. Kiessling, Polymeric nanomedicines for image-guided drug delivery and tumor-targeted combination therapy. Nano Today 5, 197-212 (2010)
  • T. Etrych, M. Šírová, L. Starovoytova, B. Říhová, K. Ulbrich, HPMA copolymer conjugates of paclitaxel and docetaxel with pH-controlled drug release. Molecular Pharmaceutics 7, 1015-1026 (2010)
  • Říhová, B., Etrych, T., Šírová, M., Kovář, L., Hovorka, O., Kovář, M., Benda, A., Ulbrich, K., Synergistic action of doxorubicin bound to the polymeric carrier based on N-(2-hydroxypropyl)methacrylamide copolymers through amide or hydrazone bond. Molecular Pharmaceutics 7, 1027-1040 (2010)
  • R. Laga, Č. Koňák, V. Šubr, K. Ulbrich, N. Suthiwangcharoen, N. Zhongwei, Q. Wang, Chemical Conjugation of Cowpea Mosaic Viruses with Reactive HPMA-Based Polymers, J. Biomater. Sci. Polym. Ed. 21(12)1669-1685 (2010)
  • P. Chytil, T. Etrych, J. Kříž, V. Šubr, K. Ulbrich, N-(2-Hydroxypropyl)-methacrylamide-based polymer conjugates with pH-controlled activation of doxorubicin for cell-specific or passive tumour targeting. Synthesis by RAFT polymerisation and physicochemical characterisation. Europ. J. Pharm. Sci. 41, 473-482 (2010)
  • R.A. Willemsen, M. Pechar, R.C. Carlisle, E. Schooten, R. Pola, A.J. Thompson, L.W. Seymour and K. Ulbrich, Multi-component polymeric system for tumour cell-specific gene delivery using a universal bungarotoxin linker. Pharm. Res. 11 (27), 2274-2282, (2010)

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News

25.07.19

Luboš Perek is celebrating his 100th year

Founding fellow of the Learned Society and its doyen, astronomer doc. RNDr. Luboš Perek, DrSc, is celebrating his 100th birthday on 26 July 2019. He is an indelible part of history as the person who helped define cosmic space, he was the first to point out the issue of cosmic waste and was also a teacher to the most important Czechoslovak astronomers. Let us express our respect and admiration of the extraordinary scientific career of a person who worked tirelessly and continues to work. The Learned Society wishes Mr Perek health, optimism and joy in the oncoming years.

23.07.19

The Academy of Sciences of the Czech Republic has appealed to the Hungarian President to support academic freedom

On Friday 19 July the Academy of Sciences of the Czech Republic and the Learned Society of the Czech Republic sent a letter to Hungarian President János Ánder, in which they state their concerns regarding the situation in respect to management and funding of scientific activities in Hungary. An act, according to which not the Academy of Sciences, but a thirteen-member political committee, will decide on research, funding of scientific activities and establishment or closure of scientific workplaces, will come into force on 1 September.

07.07.19

The loss of Learned Society Fellow prof. Josef Koutecký

We regret to inform that prof. Josef Koutecký, a fellow of the Learned Society, a renowned physician and the founder of paediatric oncology in this country, passed away on 5 July 2019 at the age of 88. He founded paediatric oncology here in 1964 and a separate paediatric oncology department was then established at the Faculty Hospital in Motol, Prague in 1978.