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Hirsch Ivan

Doc., RNDr., CSc.
Born May 19, 1946 in Prague

  • Virology, Innate immunity
  • Member of Learned Society since 2019

Educational and professional preparation

  • 1970 Master Degree (Faculty of Sciences, Charles University, Prague, Czechoslovakia) 
  • 1978 PhD (Candidate of Sciences, Czechoslovak Academy of Sciences)
  • 2013 Research Director Emeritus, INSERM, CRCM, France
  • 2014 Adjunct professor, Institute of Organic Chemistry and Biochemistry, AS CR
  • 2017 Associated professor (Faculty of Sciences, Charles University)

Employment and academic positions

  • 2013-2019 Head, Department of Genetics and Microbiology, Faculty of Science, Biocev, Charles University in Prague
  • 2014-present Adjunct professor, Institute of organic chemistry and biochemistry, Prague
  • 2013-present Research Director Emeritus; Inserm U1068, Marseille Cancer Research Center, France
  • 1992-2013 (21 years) Research Director, Inserm (Institut National de la Santé et de la Recherche Médicale), organization analogical to NIH in US.
  • Inserm U1068, Marseille Cancer Research Center (CRCM) (2005-2013)
  • Inserm U372, Laboratory of Pathogenesis of Lentiviral Infections (1998-2005)
  • Inserm U322, Laboratory of Retroviruses and Associated Diseases (1992-98)
  • 2006 (2 months) Visiting Scientist, Laboratory of Cellular and Molecular Biophysics, NICHD, National Institutes of Health (NIH), Bethesda, MD, USA
  • 1989-1992 Senior Postdoctoral Fellow, Unit of Retroviruses and Associated Diseases, Inserm U322, Marseille, France
  • 1976-1989 Senior Scientist, Institute of Sera and Vaccines, Prague, Czechoslovakia
  • 1975-1976 (1 year) Postdoctoral Fellow, Department of Virology and Epidemiology, Baylor College of Medicine, Houston, Texas, USA
  • 1975 (1 month): EMBO Course of Molecular Virology. University of Glasgow, Institute of Virology, [Director: John Subak-Sharpe].
  • 1972-1975 Research Associate, Department of Experimental Virology, Institute of Sera and Vaccines, Prague, Czechoslovakia (Chairman Prof. V. Vonka).

Membership in selected domestic scientific bodies

  • Scientific Council of the Biology Section of Faculty of Science of Charles University
  • Czech Science Foundation (GAČR) evaluation panel in Medical and Biological Sciences: Morphological disciplines, microbiology, immunology, epidemiology and Hygiene
  • Board of the doctoral study program (SAB) Microbiology. Faculty of Food and Biochemical Technology, University of Chemistry and Technology (UCT), Prague.
  • Board of the doctoral study program (SAB) Molecular and cell biology, genetics and virology. Faculty of Science, Charles University, Prague
  • Member of the Scientific Council of the Institute of Sera and Vaccines, Prague, Czechoslovakia (1976-1989)

Membership and positions in selected international organizations and societies

  • ANRS Réseau National Hépatite, Nationale Agency for AIDS and Viral Hepatitis Research
  • Société de Biologie Cellulaire de France (SBCF)
  • Club Francophone des Cellules Dendritiques (CFCD)

Notable awards

  • DR2 Research Director, Inserm
  • Senior postdoctoral fellowship ANRS 1989-1992
  • Prix Isabelle Decazes de Noue for 1978 (On advice of the Selection Committee of the International Agency for Research on Cancer, WHO, Lyon, FRANCE)

Selected publications

  • Hepatitis B virus evasion from cGAS sensing in human hepatocytes. Verrier ER, Yim SA, Heydmann L, El Saghire H, Bach C,Turon-Lagot V, Mailly L, Durand SC, Lucifora J, Durantel D, Pessaux P, Manel N,Hirsch I, Zeisel MB, Pochet N, Schuster C, Baumert TF (2018) Hepatology
  • HRas signal transduction promotes hepatitis C virus cell entry by triggering assembly of the host tetraspanin receptor complex. Zona L, Lupberger J, Sidahmed-Adrar N, Thumann C, Harris HJ, Barnes A, Florentin J, Tawar RG, Xiao F, Turek M, Durand SC, Duong FH, Heim MH, Cosset FL, Hirsch I, Samuel D, Brino L, Zeisel MB, Le Naour F, McKeating JA, Baumert TF. (2013). Cell Host Microbe. 13 (3):302-13.
  • HCV glycoprotein E2 is a novel BDCA-2 ligand and acts as an inhibitor of IFN production by plasmacytoid dendritic cells. Florentin J, Aouar B, Dental C, Thumann C, Firaguay G, Gondois-Rey F, Soumelis V, Baumert TF, Nunès JA, Olive D, Hirsch I, Stranska R. (2012). Blood; 120(23):4544-51.
  • Impaired Toll-like receptor 7 and 9 signaling: from chronic viral infections to cancer. Hirsch, I., Caux, C., Hasan, U., Bendriss-Vermare, N., and Olive, D. (2010). Trends Immunol 31 (10), 391-7
  • CpG methylation controls reactivation of HIV from latency. Blazkova, J., Trejbalova, K., Gondois-Rey, F., Halfon, P., Philibert, P., Guiguen, A., Verdin, E., Olive, D., Van Lint, C., Hejnar, J., and Hirsch, I. (2009). PLoS Pathog 5 (8), e1000554. Three times commented in Faculty of 1000 Medicine
  • HIV-1 induced activation of CD4+ T cells creates new targets for HIV-1 infection in human lymphoid tissue ex vivo. Biancotto, A., Iglehart, S. J., Vanpouille, C., Condack, C. E., Lisco, A., Ruecker, E., Hirsch, I., Margolis, L. B., and Grivel, J. C. (2008). Blood 111 (2), 699-704.
  • Dual role of prostratin in inhibition of infection and reactivation of human immunodeficiency virus from latency in primary blood lymphocytes and lymphoid tissue. Biancotto, A., Grivel, J. C., Gondois-Rey, F., Bettendroffer, L., Vigne, R., Brown, S., Margolis, L. B., and Hirsch, I. (2004). J Virol 78 (19), 10507-15.
  • Discrepancies in AIDS virus data. Chermann, J. C., Donker, G., Yahi, N., Salaun, D., Guettari, N., Gayet, O., and Hirsh, I. (1991). Nature 351 (6324), 277-8
  • Prospective study on the relationship between cervical neoplasia and herpes simplex type-2 virus. II. Herpes simplex type-2 antibody presence in sera taken at enrollment. Vonka, V., Kanka, J., Hirsch, I., Zavadova, H., Krcmar, M., Suchankova, A., Rezacova, D., Broucek, J., Press, M., Domorazkova, E., and et al. (1984). Int J Cancer 33 (1), 61-6.

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News

25.07.19

Luboš Perek is celebrating his 100th year

Founding fellow of the Learned Society and its doyen, astronomer doc. RNDr. Luboš Perek, DrSc, is celebrating his 100th birthday on 26 July 2019. He is an indelible part of history as the person who helped define cosmic space, he was the first to point out the issue of cosmic waste and was also a teacher to the most important Czechoslovak astronomers. Let us express our respect and admiration of the extraordinary scientific career of a person who worked tirelessly and continues to work. The Learned Society wishes Mr Perek health, optimism and joy in the oncoming years.

23.07.19

The Academy of Sciences of the Czech Republic has appealed to the Hungarian President to support academic freedom

On Friday 19 July the Academy of Sciences of the Czech Republic and the Learned Society of the Czech Republic sent a letter to Hungarian President János Ánder, in which they state their concerns regarding the situation in respect to management and funding of scientific activities in Hungary. An act, according to which not the Academy of Sciences, but a thirteen-member political committee, will decide on research, funding of scientific activities and establishment or closure of scientific workplaces, will come into force on 1 September.

07.07.19

The loss of Learned Society Fellow prof. Josef Koutecký

We regret to inform that prof. Josef Koutecký, a fellow of the Learned Society, a renowned physician and the founder of paediatric oncology in this country, passed away on 5 July 2019 at the age of 88. He founded paediatric oncology here in 1964 and a separate paediatric oncology department was then established at the Faculty Hospital in Motol, Prague in 1978.