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Hocek Michal

Prof., Ing., CSc., DSc.
Born December 11, 1969 in Benešov

  • Bioorganic and medicinal chemistry
  • Member of Learned Society since 2017

Educational and professional preparation

  • 1988-1993 undergraduate study, Prague Institute of Chemical Technology, M. S. degree
  • 1993-1996 Ph.D. study, Institute of Organic Chemistry and Biochemistry (IOCB) , Academy of Sciences of the Czech Republic (supervisor Dr. A. Holý)
  • 1997 post-doctoral stay at the Department of Chemistry, Université Catholique de Louvain, Louvain-la-Neuve, Belgium (Prof. L. Ghosez)
  • 2006 DSc. degree at the Academy of Sciences of the Czech Republic
  • 2006 habilitation at the Institute of Chemical Technology Prague - Associate professor
  • 2014 named full-professor at the Charles University

Employment and academic positions

  • 1998-2002 - staff scientist at the IOCB ASCR
  • 2003 - now - Head of a Senior research group at the IOCB ASCR
  • 2011 - now - Associate and (since 2014) full-professor (part-time) at the Faculty of Science, Charles University in Prague

Membership in selected domestic scientific bodies

  • Czech Chemical Society

Membership and positions in selected international organizations and societies

  • 1998-2011 - journal Collect. Czech. Chem. Commun. - Editor-in-Chief
  • 2011-now - journal ChemBioChem - member of the Editorial Advisory Board
  • 2011-now - journal ChemPlusChem - co-chairman of the Editorial Board
  • 2013-now - F1000 faculty member for Chemical biology
  • Americal Chemical Society - member
  • International Society for Nucleosides, Nucleotides and Nucleic Acids - member

Notable awards

  • 1999 Alfred Bader Prize for excellent results of young scientist in organic and bioorganic chemistry
  • 2004 Otto Wichterle Premium for Younger Scientists
  • 2004 Prize of the Academy of Sciences for Younger Scientists
  • 2015 Praemium Academiae from the Czech Academy of Sciences

Selected publications

  • Raindlová, V.; Pohl, R.; Šanda, M.; Hocek, M. "Direct polymerase synthesis of reactive aldehyde-functionalized DNA and its conjugation and staining with hydrazines" Angew. Chem. Int. Ed. 2010, 49, 1064-1066.
  • Nauš, P.; Pohl, R.; Votruba, I.; Džubák, P.; Hajdúch, M.; Ameral, R.; Birkuš, G.; Wang, T.; Ray, A. S.; Mackman, R.; Cihlar, T.; Hocek, M. "6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents" J. Med. Chem. 2010, 53, 460-470.
  • Bourderioux, A.; Nauš, P.; Perlíková, P.; Pohl, R.; Pichová, I.; Votruba, I.; Džubák, P.; Konečný, P.; Hajdúch, M.; Stray, K. M.; Wang, T.; Ray, A. S.; Feng, J. Y.; Birkus, G.; Cihlar, T.; Hocek, M. "Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines" J. Med. Chem. 2011, 54, 5498-5507.
  • Kielkowski, P.; Macíčková-Cahová, H.; Pohl, R.; Hocek, M. "Transient and switchable (triethylsilyl)ethynyl protection of DNA against cleavage by restriction endonucleases" Angew. Chem. Int. Ed. 2011, 50, 8727-8730.
  • Dadová, J.; Orság, P.; Pohl, R.; Brázdová, M.; Fojta, M.; Hocek, M. "Vinylsulfonamide and acrylamide modification of DNA for cross-linking with proteins" Angew. Chem. Int. Ed. 2013, 52, 10515-10518.
  • Vaníková, Z.; Hocek, M. "Polymerase Synthesis of Photocaged DNA Resistant against Cleavage by Restriction Endonucleases" Angew. Chem. Int. Ed. 2014, 53, 6734-6737.
  • Kielkowski, P.; Fanfrlík, J.; Hocek, M. "7-Aryl-7-deazaadenine 2'-Deoxyribonucleoside Triphosphates (dNTPs): Better Substrates for DNA polymerases than dATP in Competitive Incorporations" Angew. Chem. Int. Ed. 2014, 53, 7552-7555.
  • Balintová, J.;  Špaček, J.; Pohl, R.; Brázdová, M.; Havran, L.; Fojta, M.; Hocek, M. "Azidophenyl as a click-transformable redox label of DNA suitable for electrochemical detection of DNA-protein interactions" Chem. Sci. 2015, 6, 575-587.
  • Dziuba, D.; Jurkiewicz, P.; Cebecauer, M.; Hof, M.; Hocek, M. "A Rotational Bodipy-Nucleotide: An Environment-Sensitive Fluorescence-Lifetime Probe for DNA Interactions and Applications in Live-Cell Microscopy" Angew. Chem. Int. Ed. 2016, 55, 174-178.
  • Raindlová, V.; Janoušková, M.; Slavíčková, M.; Perlíková, P.; Boháčová, S.; Milisavljevic, N.; Šanderová, H.; Benda, M.; Barvík, I.; Krasný, L.; Hocek, M. "Influence of major-groove chemical modifications of DNA on transcription by bacterial RNA polymerases" Nucleic Acids Res. 2016, 44, 3000-3012.

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News

25.07.19

Luboš Perek is celebrating his 100th year

Founding fellow of the Learned Society and its doyen, astronomer doc. RNDr. Luboš Perek, DrSc, is celebrating his 100th birthday on 26 July 2019. He is an indelible part of history as the person who helped define cosmic space, he was the first to point out the issue of cosmic waste and was also a teacher to the most important Czechoslovak astronomers. Let us express our respect and admiration of the extraordinary scientific career of a person who worked tirelessly and continues to work. The Learned Society wishes Mr Perek health, optimism and joy in the oncoming years.

23.07.19

The Academy of Sciences of the Czech Republic has appealed to the Hungarian President to support academic freedom

On Friday 19 July the Academy of Sciences of the Czech Republic and the Learned Society of the Czech Republic sent a letter to Hungarian President János Ánder, in which they state their concerns regarding the situation in respect to management and funding of scientific activities in Hungary. An act, according to which not the Academy of Sciences, but a thirteen-member political committee, will decide on research, funding of scientific activities and establishment or closure of scientific workplaces, will come into force on 1 September.

07.07.19

The loss of Learned Society Fellow prof. Josef Koutecký

We regret to inform that prof. Josef Koutecký, a fellow of the Learned Society, a renowned physician and the founder of paediatric oncology in this country, passed away on 5 July 2019 at the age of 88. He founded paediatric oncology here in 1964 and a separate paediatric oncology department was then established at the Faculty Hospital in Motol, Prague in 1978.