Calendar

09.04.2019

Public lecture

Arranged by: Section III, Biological and Medical Sciences  Lecture: Doc. Jan Pokorný: The Neglected Role of Vegetation in Distributing Solar Energy and Shaping Climate

23.04.2019

Meeting

2nd segment: arranged by Section I, Mathematics and Physical Sciences Lecture: Prof. RNDr. Martin Loebl, CSc. (Charles University Faculty of Mathematics and Physics): “Paths”The lecture is to be held on 23 April 2019 from 4:00 pm in rooms 205 and 206 of the Czech Academy of Sciences building, Národní 3, Prague 1.

20. – 21.05.2019

XXV AGM

20. 5 Karolinum – all day, evening: Vila Lanna21. 5. CAS building, all day

Hocek Michal

Prof., Ing., CSc., DSc.
Born December 11, 1969 in Benešov

  • Bioorganic and medicinal chemistry
  • Member of Learned Society since 2017

Educational and professional preparation

  • 1988-1993 undergraduate study, Prague Institute of Chemical Technology, M. S. degree
  • 1993-1996 Ph.D. study, Institute of Organic Chemistry and Biochemistry (IOCB) , Academy of Sciences of the Czech Republic (supervisor Dr. A. Holý)
  • 1997 post-doctoral stay at the Department of Chemistry, Université Catholique de Louvain, Louvain-la-Neuve, Belgium (Prof. L. Ghosez)
  • 2006 DSc. degree at the Academy of Sciences of the Czech Republic
  • 2006 habilitation at the Institute of Chemical Technology Prague - Associate professor
  • 2014 named full-professor at the Charles University

Employment and academic positions

  • 1998-2002 - staff scientist at the IOCB ASCR
  • 2003 - now - Head of a Senior research group at the IOCB ASCR
  • 2011 - now - Associate and (since 2014) full-professor (part-time) at the Faculty of Science, Charles University in Prague

Membership in selected domestic scientific bodies

  • Czech Chemical Society

Membership and positions in selected international organizations and societies

  • 1998-2011 - journal Collect. Czech. Chem. Commun. - Editor-in-Chief
  • 2011-now - journal ChemBioChem - member of the Editorial Advisory Board
  • 2011-now - journal ChemPlusChem - co-chairman of the Editorial Board
  • 2013-now - F1000 faculty member for Chemical biology
  • Americal Chemical Society - member
  • International Society for Nucleosides, Nucleotides and Nucleic Acids - member

Notable awards

  • 1999 Alfred Bader Prize for excellent results of young scientist in organic and bioorganic chemistry
  • 2004 Otto Wichterle Premium for Younger Scientists
  • 2004 Prize of the Academy of Sciences for Younger Scientists
  • 2015 Praemium Academiae from the Czech Academy of Sciences

Selected publications

  • Raindlová, V.; Pohl, R.; Šanda, M.; Hocek, M. "Direct polymerase synthesis of reactive aldehyde-functionalized DNA and its conjugation and staining with hydrazines" Angew. Chem. Int. Ed. 2010, 49, 1064-1066.
  • Nauš, P.; Pohl, R.; Votruba, I.; Džubák, P.; Hajdúch, M.; Ameral, R.; Birkuš, G.; Wang, T.; Ray, A. S.; Mackman, R.; Cihlar, T.; Hocek, M. "6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents" J. Med. Chem. 2010, 53, 460-470.
  • Bourderioux, A.; Nauš, P.; Perlíková, P.; Pohl, R.; Pichová, I.; Votruba, I.; Džubák, P.; Konečný, P.; Hajdúch, M.; Stray, K. M.; Wang, T.; Ray, A. S.; Feng, J. Y.; Birkus, G.; Cihlar, T.; Hocek, M. "Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines" J. Med. Chem. 2011, 54, 5498-5507.
  • Kielkowski, P.; Macíčková-Cahová, H.; Pohl, R.; Hocek, M. "Transient and switchable (triethylsilyl)ethynyl protection of DNA against cleavage by restriction endonucleases" Angew. Chem. Int. Ed. 2011, 50, 8727-8730.
  • Dadová, J.; Orság, P.; Pohl, R.; Brázdová, M.; Fojta, M.; Hocek, M. "Vinylsulfonamide and acrylamide modification of DNA for cross-linking with proteins" Angew. Chem. Int. Ed. 2013, 52, 10515-10518.
  • Vaníková, Z.; Hocek, M. "Polymerase Synthesis of Photocaged DNA Resistant against Cleavage by Restriction Endonucleases" Angew. Chem. Int. Ed. 2014, 53, 6734-6737.
  • Kielkowski, P.; Fanfrlík, J.; Hocek, M. "7-Aryl-7-deazaadenine 2'-Deoxyribonucleoside Triphosphates (dNTPs): Better Substrates for DNA polymerases than dATP in Competitive Incorporations" Angew. Chem. Int. Ed. 2014, 53, 7552-7555.
  • Balintová, J.;  Špaček, J.; Pohl, R.; Brázdová, M.; Havran, L.; Fojta, M.; Hocek, M. "Azidophenyl as a click-transformable redox label of DNA suitable for electrochemical detection of DNA-protein interactions" Chem. Sci. 2015, 6, 575-587.
  • Dziuba, D.; Jurkiewicz, P.; Cebecauer, M.; Hof, M.; Hocek, M. "A Rotational Bodipy-Nucleotide: An Environment-Sensitive Fluorescence-Lifetime Probe for DNA Interactions and Applications in Live-Cell Microscopy" Angew. Chem. Int. Ed. 2016, 55, 174-178.
  • Raindlová, V.; Janoušková, M.; Slavíčková, M.; Perlíková, P.; Boháčová, S.; Milisavljevic, N.; Šanderová, H.; Benda, M.; Barvík, I.; Krasný, L.; Hocek, M. "Influence of major-groove chemical modifications of DNA on transcription by bacterial RNA polymerases" Nucleic Acids Res. 2016, 44, 3000-3012.

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News

14.03.19

Invitation to a Learned Society plenary lecture open to the public

The Learned Society warmly invites you to a lecture by Prof. RNDr. Martin Loebl, CSc. (Charles University Faculty of Mathematics and Physics): “Paths”
The lecture is to be held on 23 April 2019 from 4:00 pm in rooms 205 and 206 of the Czech Academy of Sciences building, Národní 3, Prague 1.

10.03.19

Declaration of support for the student climate strikes

Declaration by the below signed members of the Learned Society and other scientists giving their support for the 15 March 2019 student climate strikes
Declaration (PDF, 36 kB)

04.02.19

Invitation to a Learned Society plenary lecture open to the public

The Learned Society warmly invites you to a lecture by PharmDr. Jitka Palich Fučíková (2nd Faculty of Medicine and Motol University Hospital): “Immunotherapy: the Present and Future”. The lecture is to be held on 19 February 2019 from 4.00 pm in Rooms 205 and 206 of the Czech Academy of Sciences building, Národní 3, Prague 1.