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Hocek Michal

Prof., Ing., CSc., DSc.
Born December 11, 1969 in Benešov

  • Bioorganic and medicinal chemistry
  • Member of Learned Society since 2017

Educational and professional preparation

  • 1988-1993 undergraduate study, Prague Institute of Chemical Technology, M. S. degree
  • 1993-1996 Ph.D. study, Institute of Organic Chemistry and Biochemistry (IOCB) , Academy of Sciences of the Czech Republic (supervisor Dr. A. Holý)
  • 1997 post-doctoral stay at the Department of Chemistry, Université Catholique de Louvain, Louvain-la-Neuve, Belgium (Prof. L. Ghosez)
  • 2006 DSc. degree at the Academy of Sciences of the Czech Republic
  • 2006 habilitation at the Institute of Chemical Technology Prague - Associate professor
  • 2014 named full-professor at the Charles University

Employment and academic positions

  • 1998-2002 - staff scientist at the IOCB ASCR
  • 2003 - now - Head of a Senior research group at the IOCB ASCR
  • 2011 - now - Associate and (since 2014) full-professor (part-time) at the Faculty of Science, Charles University in Prague

Membership in selected domestic scientific bodies

  • Czech Chemical Society

Membership and positions in selected international organizations and societies

  • 1998-2011 - journal Collect. Czech. Chem. Commun. - Editor-in-Chief
  • 2011-now - journal ChemBioChem - member of the Editorial Advisory Board
  • 2011-now - journal ChemPlusChem - co-chairman of the Editorial Board
  • 2013-now - F1000 faculty member for Chemical biology
  • Americal Chemical Society - member
  • International Society for Nucleosides, Nucleotides and Nucleic Acids - member

Notable awards

  • 1999 Alfred Bader Prize for excellent results of young scientist in organic and bioorganic chemistry
  • 2004 Otto Wichterle Premium for Younger Scientists
  • 2004 Prize of the Academy of Sciences for Younger Scientists
  • 2015 Praemium Academiae from the Czech Academy of Sciences

Selected publications

  • Raindlová, V.; Pohl, R.; Šanda, M.; Hocek, M. "Direct polymerase synthesis of reactive aldehyde-functionalized DNA and its conjugation and staining with hydrazines" Angew. Chem. Int. Ed. 2010, 49, 1064-1066.
  • Nauš, P.; Pohl, R.; Votruba, I.; Džubák, P.; Hajdúch, M.; Ameral, R.; Birkuš, G.; Wang, T.; Ray, A. S.; Mackman, R.; Cihlar, T.; Hocek, M. "6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents" J. Med. Chem. 2010, 53, 460-470.
  • Bourderioux, A.; Nauš, P.; Perlíková, P.; Pohl, R.; Pichová, I.; Votruba, I.; Džubák, P.; Konečný, P.; Hajdúch, M.; Stray, K. M.; Wang, T.; Ray, A. S.; Feng, J. Y.; Birkus, G.; Cihlar, T.; Hocek, M. "Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines" J. Med. Chem. 2011, 54, 5498-5507.
  • Kielkowski, P.; Macíčková-Cahová, H.; Pohl, R.; Hocek, M. "Transient and switchable (triethylsilyl)ethynyl protection of DNA against cleavage by restriction endonucleases" Angew. Chem. Int. Ed. 2011, 50, 8727-8730.
  • Dadová, J.; Orság, P.; Pohl, R.; Brázdová, M.; Fojta, M.; Hocek, M. "Vinylsulfonamide and acrylamide modification of DNA for cross-linking with proteins" Angew. Chem. Int. Ed. 2013, 52, 10515-10518.
  • Vaníková, Z.; Hocek, M. "Polymerase Synthesis of Photocaged DNA Resistant against Cleavage by Restriction Endonucleases" Angew. Chem. Int. Ed. 2014, 53, 6734-6737.
  • Kielkowski, P.; Fanfrlík, J.; Hocek, M. "7-Aryl-7-deazaadenine 2'-Deoxyribonucleoside Triphosphates (dNTPs): Better Substrates for DNA polymerases than dATP in Competitive Incorporations" Angew. Chem. Int. Ed. 2014, 53, 7552-7555.
  • Balintová, J.;  Špaček, J.; Pohl, R.; Brázdová, M.; Havran, L.; Fojta, M.; Hocek, M. "Azidophenyl as a click-transformable redox label of DNA suitable for electrochemical detection of DNA-protein interactions" Chem. Sci. 2015, 6, 575-587.
  • Dziuba, D.; Jurkiewicz, P.; Cebecauer, M.; Hof, M.; Hocek, M. "A Rotational Bodipy-Nucleotide: An Environment-Sensitive Fluorescence-Lifetime Probe for DNA Interactions and Applications in Live-Cell Microscopy" Angew. Chem. Int. Ed. 2016, 55, 174-178.
  • Raindlová, V.; Janoušková, M.; Slavíčková, M.; Perlíková, P.; Boháčová, S.; Milisavljevic, N.; Šanderová, H.; Benda, M.; Barvík, I.; Krasný, L.; Hocek, M. "Influence of major-groove chemical modifications of DNA on transcription by bacterial RNA polymerases" Nucleic Acids Res. 2016, 44, 3000-3012.

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News

07.05.19

XXV. General Assembly

The Czech Learned Society is holding its XXV. General Assembly on 20 and 21 May 2019. The Learned Society’s awards in the “Young Scientist” and “Grammar School Student” categories, Teaching Awards for pedagogic workers who promote interest in science and research at grammar schools and the Learned Society’s medals for meritorious contributions to the advance of science will be presented during a ceremony on 20 May at the Karolinum. Lectures by renowned scientists will also be presented. The second day will be reserved for the working part of the meeting, in the building of the Academy of Sciences of the Czech Republic.

06.05.19

Document on issues concerning the concept of European historiography and the present-day EU

Learned Society Fellow prof. Jiří Pešek signed a Document on issues concerning the concept of European historiography and the present-day EU.

05.05.19

Invitation to the Bolzano Lecture

Invitation to the Bolzano Lecture by prof. Kip S. Thorne on May 15, 2019 and other lectures on May 16 and May 17, 2019

Invitation (PDF, 707 kB)