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Krejčí Lumír

Doc. Mgr., Ph.D.
Born March 30, 1972 in Slavičín

  • DNA repair and recombination
  • Member of Learned Society since 2018

Educational and professional preparation

  • 1993 B.Sc in Biochemistry, Masaryk University, Brno
  • 1995 M.Sc in Biochemistry, Masaryk University, Brno
  • 2000 Ph.D. in Mol. & Cell Biology, Masaryk University, Brno
  • 2001 Masaryk University, Brno, Czech Republic, Mol. Biology
  • 2000 UTHSCSA, Texas, USA, Biochemistry/Mol. Biol.
  • 2003 Yale University, New Haven, USA, Biochemistry/Mol. Biol.
  • 2013 Associate professor in Medical Biology, Masaryk University, Brno

Employment and academic positions

  • 1995-1997 graduate fellow, Department of Molecular Biology, Aarhus University, Denmark
  • 1997-2000 graduate fellow, Danish Institute of Agricultural Science, Denmark
  • 2000-2001 research scientist, Masaryk University, Brno, Czech Republic
  • 2001-2003 postdoctoral fellow, Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center, San Antonio, TX. (Mentor: Patrick Sung, Ph.D.)
  • 2003-2004 postdoctoral associate, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT. (Mentor: Patrick Sung, Ph.D.)
  • 2004-2005 associate research scientist, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT. (Mentor: Patrick Sung, Ph.D.)
  • 2005-present associate professor, National Centre for Biomolecular Research, Faculty of Science, Masaryk University, Brno, Czech Republic
  • 2009-present associate professor, Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
  • 2011-present senior researcher, International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic
  • 2015-2016 Vice Chair for basic research, International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic

Membership in selected domestic scientific bodies

Membership and supervision in doctoral boards:
  • member of doctoral board, Institute of Biophysics of the Czech Academy of Sciences
  • member of doctoral board, Medical Biology, Faculty of Medicine, Masaryk University
  • member of doctoral commitee, Biomolecular Chemistry, Faculty of Science, Masaryk University
  • supervisor within doctoral board of Medical Biology, Faculty of Medicine, Masaryk University
  • supervisor within Biomolecular Chemistry, Faculty of Science, Masaryk University

Ad hoc referee for grant agencies: Czech Science Foundation and others

Bioskop – Research Education Centre, Masaryk University
Council for Research, Institute of Biophysics of the CAS, v.v.i.; Czech Republic
Scientific Advisory Board for Mendel Lectures

Membership and positions in selected international organizations and societies

Ad hoc referee for Grant agencies: Wellcome Trust, Cancer Research UK, Scientific Grant Agency VEGA (Slovak Republic), European Research Council Executive Agency (ERCEA) and others
Ad hoc referee for journals: EMBO Journal, Mol. Cell, PLoS Genetics, Nucleic Acids Research, PLoS One, DNA repair, Cell cycle, Cell Reports JBC, JCB, Nature Communication, PNAS, Genes and Development and others

Notable awards

  • 2001 NATO Science Fellowship
  • 2003-2006 US DOD Postdoctoral Fellowship
  • 2005-2010 Wellcome International Science Fellowship
  • 2005-2008 EMBO/HHMI Startup Award
  • 2017 Ministry of Education Youth and Sport of the Czech Republic Award

Selected publications

  1. Coquel, F, Silva, MJ, Téche,r H, Zadorozhny, K, Sharma, S, Nieminuszczy, J, Mettling, C, Dardillac, E, Barthe, A, Schmitz, AL, Promonet, A, Cribier, A, Sarrazin, A, Niedzwiedz, W, Lopez, B, Costanzo, V, Krejci, L, Chabes, A, Benkirane, M, Lin, YL, Pasero, P. (2018) SAMHD1 acts at stalled replication forks to prevent interferon induction. Nature. 557 (57-61). DOI: 10.1038/s41586-018-0050-1.
  2. Krejci, L.*, Van Komen, S., Li, Y., Villemain, J., Reddy, M. S., Klein, H., Ellenberger, T., Sung, P. (2003) DNA helicase Srs2 disrupts the Rad51 presynaptic filament. Nature 423:305-9. Featured in Nature News & Views “Disruptive Influence” by Marco Foiani, (2003), 423:234-235. DOI: 10.1038/nature01577, IF: 30.979
  3. Zadorozhny, K, Sannino, V, Belan, O, Mlcouskova, J, Spirek, M, Costanzo, V, Krejci, L.* (2017) Fanconi-Anemia-Associated Mutations Destabilize RAD51 Filaments and Impair Replication Fork Protection. Cell Rep. 21 (2):333-340. DOI: 10.1016/j.celrep.2017.09.062, IF= 8.282
  4. Taylor MR, Špírek M, Chaurasiya KR, Ward JD, Carzaniga R, Yu X, Egelman EH, Collinson LM, Rueda D, Krejci L*, Boulton SJ. Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination. Cell. 2015 Jul 16;162(2):271-86. doi: 10.1016/j.cell.2015.06.015.
  5. Di Marco S, Hasanova Z, Kanagaraj R, Chappidi N, Altmannova V, Menon S, Sedlackova H, Langhoff J, Surendranath K, Hühn D, Bhowmick R, Marini V, Ferrari S, Hickson ID, Krejci L*, Janscak P. RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis. Mol Cell. 2017 Jun 1;66(5):658-671.e8. doi: 10.1016/j.molcel.2017.05.006.
  6. Kolinjivadi AM, Sannino V, De Antoni A, Zadorozhny K, Kilkenny M, Técher H, Baldi G, Shen R, Ciccia A, Pellegrini L, Krejci L*, Costanzo V. Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments. Mol Cell. 2017 Sep 7;67(5):867-881.e7. doi: 10.1016/j.molcel.2017.07.001.
  7. Antony E, Tomko EJ, Xiao Q, Krejci L, Lohman TM, Ellenberger T. Srs2 disassembles Rad51 filaments by a protein-protein interaction triggering ATP turnover and dissociation of Rad51 from DNA. Mol Cell. 2009 Jul 10;35(1):105-15. doi: 10.1016/j.molcel.2009.05.026.
  8. Taylor MR, Špírek M, Jian Ma C, Carzaniga R, Takaki T, Collinson LM, Greene EC, Krejci L*, Boulton SJ. A Polar and Nucleotide-Dependent Mechanism of Action for RAD51 Paralogs in RAD51 Filament Remodeling. Mol Cell. 2016 Dec 1;64(5):926-939. doi: 10.1016/j.molcel.2016.10.020.
  9. Urulangodi M, Sebesta M, Menolfi D, Szakal B, Sollier J, Sisakova A, Krejci L, Branzei D. Local regulation of the Srs2 helicase by the SUMO-like domain protein Esc2 promotes recombination at sites of stalled replication. Genes Dev. 2015 Oct 1;29(19):2067-80. doi: 10.1101/gad.265629.115.
  10. Burkovics P, Sebesta M, Sisakova A, Plault N, Szukacsov V, Robert T, Pinter L, Marini V, Kolesar P, Haracska L, Gangloff S, Krejci L* Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis. EMBO J. 2013 Mar 6;32(5):742-55. doi: 10.1038/emboj.2013.9.

• Corresponding author

Web sites:
http://www.med.muni.cz/lord/
http://biology.med.muni.cz/
http://mendellectures.muni.cz/
http://bioskop.muni.cz/

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