Závada Jan

RNDr., DrSc.
Born December 10, 1933 in Prague, † January 5, 2024

• Genetics of viruses, molecular oncology
• Member of Learned Society since 1994 (Founding member)

Educational and professional preparation:

• 1952-1956, Faculty of Natural Science, Charles University, Prague;
• 1958-1962, post-graduate student, Institute of Virology, Slovak Academy of Sciences (SAS), Bratislava

Employment:

• 1956-1992 Institute of Virology, SAS;
• 1993-present, Institute of Molecular Genetics, Academy of Sciences of Czech Republic (AS CR);
• 1965-1966, Institute of Virology, Glasgow (Scotland) (12 months),
• 1969-1975, Imperial Cancer Research Fund Laboratories, London (9 plus 6 months);
• 1982-1983, Harvard Medical School, Boston (Mass.) (12 months).

Membership and positions in international organizations and societies:

• Member, European Molecular Biology Organization
• Member, European Association for Cancer Research
• Member, European Tumour Virus Group

Notable awards:

• 1981, National prize (for the construction of viral pseudotypes and their use in diagnostics)
• 1984, Award, SAS, and Award, Czechoslovak Writers’ Federation (for the popular-scientific book The Mystery of Cancer by J. Závada and V. Vonka

Selected publications:

• J. Závada, Z. Závadová, M. Zaťovičová, L. Hyršl, I. Kawaciuk: Soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients.
  Brit. J. Cancer 89, 1067–1071 (2003)
• M. Ortová-Gut, S. Parkkila, Z. Vernerová, E. Rohde, J. Závada, M. Hocker, J. Pastorek, T. Karttunen, A. Gibadulinová, Z. Závadová, K-P. Knobeloch, B. Wiedermann, J. Svoboda, I. Horak, S. Pastoreková: Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9. Gastroenterology 123, 1889–1903 (2002)
• J. Závada, Z. Závadová, J. Pastorek, Z. Biesová, J. Ježek, J. Velek: Human tumor-associated cell adhesion protein MN/CA IX: Identification of M75 epitope and of the region mediating cell adhesion. Brit. J. Cancer 82, 1808–1813 (2000)
• R. Opavský, S. Pastoreková, V. Zelník, A. Gibadulinová, E. J. Stanbridge, J. Závada, R. Kettmann, J. Pastorek: Human MN/Ca9 gene, a novel member of the carbonic anhydrase family: Structure and exon to protein domain relationships. Genomics 33, 480–487 (1996)
• J. Závada, Z. Závadová, S. Pastoreková, F. Čiampor, J. Pastorek, V. Zelník: Expression of MaTu-MN protein in human tumor cultures and in clinical specimens. Int. J. Cancer 54, 268-274 (1993)
• J. Závada: The pseudotypic paradox. (Review article). J. Gen. Virol. 63, 15-24, (1982)
• J. Závada, L. Černý, Z. Závadová, J. Božoňová, A.D. Altstein: A rapid neutralization test for antibodies to bovine leukemia virus, with the use of rhabdovirus pseudotypes. J. Natl. Cancer Inst. 62, 95-101 (1979)
• J. Závada: Assay methods for viral pseudotypes. In Methods in Virology 6, New York, San Francisco, London, Academic Press 1977, pp. 109-142
• J. Závada: Pseudotypes of vesicular stomatitis virus with the coat of murine leukemia and of avian myeloblastosis viruses. J. Gen. Virol. 15, 183-191 (1972)

Patents:

• J. Závada, S. Pastoreková, J. Pastorek: MN Gene and Protein. US patent No. 5 387 676 (1995); other patents related to MN/CA IX: 5 955 075, 5 972 353, 5 981 711 (1999), 6 069 242, 6 093 548 (2000), 6 204 370 B1, 6 297 051 B1 (2001)
• Some of the patents have a world-wide extension of validity, all are exclusively licensed to the Bayer Corp., USA