Hocek Michal

Prof., Ing., CSc., DSc.
Born December 11, 1969 in Benešov

Bioorganic and medicinal chemistry
Member of Learned Society since 2017

Educational and professional preparation

1988-1993 undergraduate study, Prague Institute of Chemical Technology, M. S. degree
1993-1996 Ph.D. study, Institute of Organic Chemistry and Biochemistry (IOCB) , Academy of Sciences of the Czech Republic (supervisor Dr. A. Holý)
1997 post-doctoral stay at the Department of Chemistry, Université Catholique de Louvain, Louvain-la-Neuve, Belgium (Prof. L. Ghosez)
2006 DSc. degree at the Academy of Sciences of the Czech Republic
2006 habilitation at the Institute of Chemical Technology Prague - Associate professor
2014 named full-professor at the Charles University

Employment and academic positions

1998-2002 - staff scientist at the IOCB ASCR
2003 - now - Head of a Senior research group at the IOCB ASCR
2011 - now - Associate and (since 2014) full-professor (part-time) at the Faculty of Science, Charles University in Prague

Membership in selected domestic scientific bodies

Czech Chemical Society

Membership and positions in selected international organizations and societies

1998-2011 - journal Collect. Czech. Chem. Commun. - Editor-in-Chief
2011-now - journal ChemBioChem - member of the Editorial Advisory Board
2011-now - journal ChemPlusChem - co-chairman of the Editorial Board
2013-now - F1000 faculty member for Chemical biology
Americal Chemical Society - member
International Society for Nucleosides, Nucleotides and Nucleic Acids - member

Notable awards

1999 Alfred Bader Prize for excellent results of young scientist in organic and bioorganic chemistry
2004 Otto Wichterle Premium for Younger Scientists
2004 Prize of the Academy of Sciences for Younger Scientists
2015 Praemium Academiae from the Czech Academy of Sciences

Selected publications

Raindlová, V.; Pohl, R.; Šanda, M.; Hocek, M. "Direct polymerase synthesis of reactive aldehyde-functionalized DNA and its conjugation and staining with hydrazines" Angew. Chem. Int. Ed. 2010, 49, 1064-1066.
Nauš, P.; Pohl, R.; Votruba, I.; Džubák, P.; Hajdúch, M.; Ameral, R.; Birkuš, G.; Wang, T.; Ray, A. S.; Mackman, R.; Cihlar, T.; Hocek, M. "6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents" J. Med. Chem. 2010, 53, 460-470.
Bourderioux, A.; Nauš, P.; Perlíková, P.; Pohl, R.; Pichová, I.; Votruba, I.; Džubák, P.; Konečný, P.; Hajdúch, M.; Stray, K. M.; Wang, T.; Ray, A. S.; Feng, J. Y.; Birkus, G.; Cihlar, T.; Hocek, M. "Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines" J. Med. Chem. 2011, 54, 5498-5507.
Kielkowski, P.; Macíčková-Cahová, H.; Pohl, R.; Hocek, M. "Transient and switchable (triethylsilyl)ethynyl protection of DNA against cleavage by restriction endonucleases" Angew. Chem. Int. Ed. 2011, 50, 8727-8730.
Dadová, J.; Orság, P.; Pohl, R.; Brázdová, M.; Fojta, M.; Hocek, M. "Vinylsulfonamide and acrylamide modification of DNA for cross-linking with proteins" Angew. Chem. Int. Ed. 2013, 52, 10515-10518.
Vaníková, Z.; Hocek, M. "Polymerase Synthesis of Photocaged DNA Resistant against Cleavage by Restriction Endonucleases" Angew. Chem. Int. Ed. 2014, 53, 6734-6737.
Kielkowski, P.; Fanfrlík, J.; Hocek, M. "7-Aryl-7-deazaadenine 2'-Deoxyribonucleoside Triphosphates (dNTPs): Better Substrates for DNA polymerases than dATP in Competitive Incorporations" Angew. Chem. Int. Ed. 2014, 53, 7552-7555.
Balintová, J.; Špaček, J.; Pohl, R.; Brázdová, M.; Havran, L.; Fojta, M.; Hocek, M. "Azidophenyl as a click-transformable redox label of DNA suitable for electrochemical detection of DNA-protein interactions" Chem. Sci. 2015, 6, 575-587.
Dziuba, D.; Jurkiewicz, P.; Cebecauer, M.; Hof, M.; Hocek, M. "A Rotational Bodipy-Nucleotide: An Environment-Sensitive Fluorescence-Lifetime Probe for DNA Interactions and Applications in Live-Cell Microscopy" Angew. Chem. Int. Ed. 2016, 55, 174-178.
Raindlová, V.; Janoušková, M.; Slavíčková, M.; Perlíková, P.; Boháčová, S.; Milisavljevic, N.; Šanderová, H.; Benda, M.; Barvík, I.; Krasný, L.; Hocek, M. "Influence of major-groove chemical modifications of DNA on transcription by bacterial RNA polymerases" Nucleic Acids Res. 2016, 44, 3000-3012.

Web site