Lukáš Jiří

Born 31. October, 1961

Cell & cancer biology
Honorary member of the Learned Society since 2005

Educational and professional preparation:

(1981-86) Veterinary University, Brno, Czech Republic
(1987-90) Institute of Systematic and Ecological Biology, Czech Academy of Sciences, Brno, Czech Republic
(1990 & 1991) Department of Biochemistry (Paul Nurse), Oxford, UK
(1992-93) Cell Cycle Group (Giulio Draetta), EMBL, Heidelberg, Germany
Since 2005: Director, Centre for Genotoxic Stress Research
Institute of Cancer Biology, Danish Cancer Society

Research interests:

Regulation of the mammalian cell division cycle and its response to genotoxic stress
Non-invasive imaging of molecular events in living mammalian cells

Notable awards:

Fellowships: EMBO, UICC, ICRF
Grants: Human Frontier Scientific Programme; European Union (FP6), European Science Foundation, Danish Cancer Society; Danish National Research Foundation.
Young Danish Cancer Researcher Prize (1995)
Elected EMBO Member (2002)
Alfred Benzons Foundation Prize (2002)
Novo Nordisk Foundation Prize (2003)
G. J. Mendel Honorary Medal (2003)
Associated professor, Aarhus University (2005)
Honorary member of the Learned Society of the Czech Republic (2005)
Senior Researcher Prize, Danish Cancer Society (2006)

Patents:

International patent on the Cdc25A DNA damage checkpoint pathway as a target for cancer therapeutics.

Selected publications:

97 research papers in peer reviewed journals; 25 review articles; 4 book chapters.
The references of 10 key papers are provided below:

Lukas, J., Parry, D., Aagaard, L., Mann, D.J., Bartkova, J., Strauss, M., Peters, G., and Bartek, J. Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature 375, 503-506 (1995).
Lukas, C., Sørensen, C.S., Kramer, E., Santoni-Rugiu, E., Lindeneg, C., Peters, J. M., Bartek, J., and Lukas, J. Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex. Nature 401, 815-818 (1999).
Mailand, N., Falck, J., Lukas, C., Syljuåsen R., Welcker, M., Bartek, J., and Lukas, J. Rapid destruction of human Cdc25A in response to DNA damage. Science 288, 1425-1429 (2000).
Falck, J., Mailand, N., Syljuasen, R. G., Bartek, J. & Lukas, J. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 410, 842-847 (2001).
Sørensen, C. S., Syljuåsen, R. G., Falck, J., Schroeder, T., Rönnstrand, L., Zhou, B. B., Bartek, J., and Lukas, J. Chk1 regulates the S-phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell 3, 247-258 (2003).
Lukas, C., Falck, J., Bartkova, J., Bartek, J., and Lukas, J. Distinct spatio-temporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nature Cell Biology 5, 255-260 (2003).
Lukas, J., and Bartek, J. The heart of the cycle. Nature, 432, 564-567 (2004).
Bartkova, J., Horejsi, Z., Koed, K., Guldberg, P., Krämer, A., Sehested, M., Nesland, J., Lukas, C., Ørntoft, T., Lukas, J., and Bartek. J. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature, 434, 864-870 (2005).
Bartek, J., and Lukas, J. Balancing life-or-death decisions. Science, 314, 261-262 (2006).
Mailand, N., Bekker-Jensen, S., Bartek, J., and Lukas, J. Destruction of Claspin by SCF ^TrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Molecular Cell, 23, 307-318 (2006).