Novotný Miloš Vlastislav

Professor, RNDr, Dr.Sc., Dr.honoris causa (mult.)
Born on April 19, 1942, in Brno

• Analytical chemistry, biochemistry
• Foreign Member of the Learned Society since 2004

Educational and professional preparation:

• Graduated in 1959, Gymnasium Brno-Husovice
• Graduated in 1965 at the University of Brno (now Masaryk University); RNDr 1967.
• 1965 – 1968, on research staff of the Institute of Analytical Chemistry, Czechoslovak Academy of Sciences, Brno
• 1968 – 1969, Research Associate, Royal Karolinska Institute, Stockholm, Sweden
• 1969 – 1971, Robert Welch Postdoctoral Fellow, University of Houston, Texas

Employment and academic positions:

Since 1971 on the faculty of Indiana University (Bloomington, Indiana), as Assistant Professor of Chemistry (1971 – 1974), Associate Professor (1974 – 1978), Professor of Chemistry (1978 – l988), James H. Rudy Professor (1988 – 1999), Distinguished Professor (1999 – present), Lilly Chemistry Alumni Chair (2000 – present), Adjunct Professor of Medicine, Indiana University School of Medicine, Indianapolis (2004 – present).

Membership in national and international societies:

• American Chemical Society, since 1971
• Mars Viking Lander Science Team, NASA, Associate Member, 1972 – 1974
• Gordon Conference on Analytical Chemistry, Chairman in 1980
• American Association for the Advancement of Science, elected as Fellow in 1989
• Royal Society for Sciences (Sweden), elected as Foreign Member in 1999
• Slovak Pharmaceutical Society, Honorary Member, 2004

Notable awards :

• 1984: M.S. Tswett Award and Medal for Chromatography
• 1986: American Chemical Society Award in Chromatography
• 1988: ISCO Award in Biochemical Instrumentation
• 1988: Chemical Instrumentation Award of the American Chemical Society
• 1991: Marcel J.E. Golay Award and Medal for Capillary Chromatography
• 1991: Doctor honoris causa, Uppsala University, Sweden
• 1992: American Chemical Society Award in Separation Science and Technology
• 1992: Doctor honoris causa, Masaryk University
• 1994: R&D Magazine Scientist of the Year Award
• 1994: M.S. Tswett Memorial Medal of the Russian Federation
• 1994: A.J.P. Martin Gold Medal (United Kingdom)
• 2000: COLACRO (Congreso Latinoamericano de Cromatografia ) Merit Medal
• 2003: Tracy M. Sonneborn Award for Outstanding Research and Teaching, Indiana University
• 2006: American Chemical Society Award in Analytical Chemistry
• 2007: Doctor honoris causa, Charles University

Selected publications:

• Z. Kyselova, Y. Mechref, M. Al Bataineh, L. E. Dobrolecki, R.J. Hickey, C.J. Sweeney, M.V. Novotny: Alterations in the human blood serum glycome as a consequence of prostate cancer. J. Proteome Res. (2007) ; ASAP Article; DOI: 10.1021/pr060664t
• Milan Madera, Yehia Mechref, Iveta Klouckova, and Milos V. Novotny: Semiautomated high-sensitivity profiling of human blood serum glycoproteins through lectin preconcentration and multidimensional chromatography/tandem mass spectrometry, J. Proteome Research 5, 2348-2363 (2006)
• M. Madera, Y. Mechref and M. V. Novotny: Combining lectin microcolumns with high-resolution separation techniques for enrichment of glycoproteins and glycopeptides. Anal. Chem. 77, 4081 (2005)
• M.V. Novotny: Pheromones, binding proteins and receptor responses in rodents. Biochem. Soc. Transactions 31, 117 (2003)
• Y. Mechref and M.V. Novotny: Structural investigations of glycoconjugates at high sensitivity. Chemical Reviews, 102(2) 321 (2002)
• M. Sam, S. Vora, B. Malnic, W. Ma, M. V. Novotny, and L. B. Buck: Odorants may arouse instinctive behaviours. Nature 12, 142 (2001)
• D.E. Timm, L.J. Baker, H. Mueller, L. Zidek, M.V. Novotny: Structural basis of pheromone binding to mouse major urinary protein (MUP-I). Protein Science 10, 997 (2001)
• T. Leinders-Zufall, A. P. Lane, A. C. Puche, W. Ma, M. V. Novotny, M. T. Shipley and F. Zufall: Ultrasensitive and selective detection of putative pheromones by mammalian vomeronasal neurons. Nature 405, 792 (2000)
• M. Novotny, W. Ma, B. Jemiolo, D. Wiesler, S. Harvey, F. Xu, T.-M. Xie and M. Carmack: A unique urinary constituent, 6-hydroxy-6-methyl-3-heptanone, is a pheromone that accelerates puberty in female mice. Chemistry & Biology 6, 377 (1999)
• L. Zidek, M.J. Stone, S.M. Lato, A.D. Ellington, and M.V. Novotny: NMR mapping of recombinant mouse major urinary protein I binding site occupied by a pheromone, 2-sec.butyl-4,5-dihydrothiazole. Biochemistry 38, 9850 (1999)
• M.V. Novotny, W. Ma, D. Wiesler, and L. Zidek: Positive identification of the puberty-accelerating pheromone of the house mouse: the volatiles associating with the major urinary protein. Proc. Roy. Soc. Lond. B 266, 2017 (1999)
• L. Zidek, M. V. Novotny, and M. J. Stone: Increased protein backbone conformational entropy upon hydrophobic ligand binding. Nature Structural Biology 6, 1118 (1999)
• M.V. Novotny: Capillary biomolecular separations. J. Chromatogr. B 689, 55 (1997)
• P. Chen, D. Wiesler, J. Chmelik and M. Novotny: Substituted 2-hydroxy-1,2-dihydropyrrol-3-ones: fluorescent markers pertaining to oxidative stress and aging, Chem. Res. Toxicol. 9(6) 970 (1996)
• M.V. Novotny, T.-M. Xie, S. Harvey, D. Wiesler, B. Jemiolo, & M. Carmack: Stereoselectivity in mammalian chemical communication: male mouse pheromones. Experientia 51, 738 (1995)
• J. Sudor and M. V. Novotny: End-label, free-solution capillary electrophoresis of highly charged oligosaccharides. Anal. Chem., 67, 4205 (1995)
• B. Jemiolo and M. Novotny: Inhibition of sexual maturation in juvenile male and female mice by a chemosignal of female origin. Physiol. Behav. 55, 519 (1994)
• M. Stefansson and M. Novotny: Electrophoretic resolution of monosaccharide enantiomers in borate-oligosaccharide complexation media. J. Am. Chem. Soc. 115, 11573 (1993)
• K. Cobb and M. Novotny: Peptide mapping of complex proteins at the low-picomole level, with capillary electrophoretic separations. Anal. Chem. 64, 879 (1992)
• J.P. Liu, O. Shirota, D. Wiesler, and M. Novotny: Ultrasensitive fluorometric detection of carbohydrates as derivatives in mixtures separated by capillary electrophoresis. Proc. Nat. Acad. Sci. USA 88, 2302 (1991)
• M. Novotny, S. Harvey, and B. Jemiolo: Chemistry of male dominance in the house mouse, Mus domesticus. Experientia 46, 109 (1990)
• K.-E. Karlsson and M. Novotny: Separation efficiency of slurry-packed LC microcolumns with very small inner diameters. Anal. Chem. 60, 1662 (1988)
• M. Novotny, B. Jemiolo, S. Harvey, D. Wiesler, and A. Marchlewska-Koj: Adrenal-mediated endogenous metabolites inhibit puberty in female mice. Science 231, 722 (1986)
• B. Jemiolo, S. Harvey, and M. Novotny: Promotion of the Whitten effect in female mice by the synthetic analogs of male urinary constituents. Proc. Natl. Acad. Sci. USA 83, 4576 (1986)
• M. Novotny, S. Harvey, B. Jemiolo, and J. Alberts: Synthetic pheromones that promote inter-male aggression in mice. Proc. Natl. Acad. Sci. USA 82, 2059 (1985)
• G. Rhodes, M.L. Holland, D. Wiesler, M. Novotny, D.L. Felton, R.G. Peterson, and S.A. Moore: Structural relationships between the endogenous volatile urinary metabolites of experimentally diabetic rats and certain neurotoxins. Experientia 38, 75 (1982)
• M. Novotny, S.R. Springston, P.A. Peaden, J.C. Fjeldsted, and M.L. Lee: Capillary supercritical-fluid chromatography. Anal. Chem. 53, 407A (1981)
• T. Tsuda and M. Novotny: Packed microcapillary columns in high-performance liquid chromatography. Anal. Chem. 50, 271 (1978)
• J.W. Jorgenson, M. Novotny, G.B. Copland, S.R. Wilson, S. Katona, and W.K. Whitten: Chemical scent constituents in the urine of the red fox (Vulpes vulpes L.) during the winter season. Science 199, 796 (1978)
• M. Novotny ,J.M. Hayes, F. Bruner, and P.G. Simmonds: Gas-chromatographic column for the Viking 1975 molecular analysis experiment. Science 189, 215 (1975)