Popovič Mikuláš

M.D., Ph.D.
Born August 12. 1941 in Mukachevo, Transcarpathia, Hungary (currently Ukraine);
U.S. citizen

Honorary Member of Learned Society since 2002

Educational and professional preparation:

1959, graduate, ”stare gymnazium z roku 1908“, Bratislava, Czechoslovakia;
1959-1965, Medical Faculty, Comenius University, Bratislava;
1965-1970, Graduate study in virology and cytopathology, Cancer Research Institute (CRI), Slovak Academy of Science (SAS), Bratislava and at Institute of Experimental Biology (Institute of Molecular Genetics), Czechoslovak Academy of Sciences, Prague, mentor: Professor Jan Svoboda, Dr.Sc;
1966-1967, Military service in Czechoslovak Air Force as physician, Mosnov, Moravska Ostrava;
1971, Ph.D., CRI, SAS

Employment and Appointments:

1965-1973, Graduate student and Junior Scientific Officer, CRI;
1973-1974, Fellow of Swedish Cancer Society, University of Uppsala, Uppsala Sweden;
1974-1981, Senior Research Scientist and Head of Viral Carcinogenesis Laboratory, CRI, SAS;
1980-1981, American Cancer Society Fellow, National Cancer Institute, National Institute of Health, Bethesda, Maryland (USA);
1982-1983, Visiting Associate, Laboratory of Tumor Cell Biology, National Cancer Institute, National Institute of Health, Bethesda;
1984-1987, Visiting Scientist, at the same Laboratory and Institute;
1988-1989, Senior Investigator, Laboratory of Tumor Cell Biology, National Cancer Institute, National Institute of Health, Bethesda;
1989-1990, Research Professor, Head of Department of Virology and Immunology, Primate Research Institute, New Mexico State University, Alamogordo, New Mexico (USA);
1991, Visiting Scientist, Deutsches Primatenzentrum, Gottingen, Germany;
1992, Consultant, Ajinomoto Co., Biotech Research Laboratory, Inc., Rockville, Maryland;
1993,Senior Research Scientist, Department of Cell Biology, Advanced Bioscience Laboratories, Inc., Rockville;
1993-1996, Visiting Scientist, Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm, (Sweden);
1996-present, Professor, Head of Laboratory of Viral Pathogenesis, Institute of Human Virology, University of Maryland Biotechnology Centers, Baltimore, Maryland;
1997-present, Professor, Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore

Membership and positions in international organizations and societies:

1984, member, American Association for the Advancement of Sciences
1986, member, New York Academy of Sciences
1994, fellow, American Academy of Microbiology

Notable awards:

1973, International Fellowship, Swedish Cancer Society
1979, Eleanor Roosevelt International Cancer Fellowship, International Union Against Cancer (UICC) Geneva (Switzerland)
1985, Inventors‘ Award, US Department of Commerce, National Technical Information Service, Washington, DC
1986, Recognition and Appreciation for Submission of an Invention Beneficial to the Government , U.S. Department of Health and Human Services, Washington, DC
1986, Outstanding Invention Award, Bio-Expo ’86. Boston, Massachusetts (USA)
1992, Among 100 most-cited authors during period 1981-1990 (in Theoretical Medicine by E.Garfield and A.Welljams-Dorof, Current Contents, August 31, 1992.) A letter of recognition from Lance A. Liotta, M.D., Ph.D., Deputy Director for Intramural Research, National Institute of Health, Bethesda
1993, Among the top 20 contributors to Cell, Nature, and Science, January 1981-June 1992 (in The Journal of NIH Research, May 1993, Vol.5., p. 33)
1994, Genetic Modification (GM) Professorship Lecture, Institute of Molecular Genetics, Prague
1995, Carrier Achievement Award, Laboratory of Tumor Cell Biology, National Cancer Institute, National Institute of Health, Bethesda
1996, Doctor Honoris Causa, SAS

Notable publications:

Agwale S. M., Shata M. T., Reitz M. S, Jr., Kalyanaraman V. S., Gallo R. C., Popovic M., Hone D. M.: A Tat Subunite vaccine confers protective immunity against immune modulating activity of human immunodeficiency virus type-1 Tat protein in mice. Proc Natl. Acad Sci USA 99: 10037-100041, 2002.
Gartner S., Markovits P., Markovits D., Kaplan M. H., Gallo R. C., Popovic M.: The role of mononuclear phagocytes in HTLV-III/LAV infection. Science 233: 215-219, 1986.
Popovic M., Flomenberg N., Volkman D. J., Mann D., Fauci A. A., Dupont B., Gallo R. C.: Alteration of specific T-cell function by HTLV-I and HTLV-II infection. Science 226, 459-462, 1984.
Popovic M., Lange-Wantzin G., Sarin P. S., Mann D., Gallo R. C.: Transformation of human umbilical cord blod T-cells by human T-cell leukemia/lymphoma virus (HTLV). Proc Natl Acad Sci USA 80, 5402-5406, 1983.
Popovic M., Sarngadharan M. G., Read R., Gallo, R. C.: Detection, isolation, and continuous production of cytopathic human T-lymphotropic retrovirus (HTLV-III) from patients with AIDS and pre-AIDS. Science 224, 497-500, 1984.
Sarngadharan M. G., Popovic M., Bruch L., Schüpbach J., Gallo R. C.: Antibodies reactive with a human T-lymphotropic retrovirus (HTLV-III) in the sera of patiens with AIDS. Science 224, 506-508, 1984.
Popovic M., Sarin P. S., Robert-Guroff M., Kalyanaraman V. S., Mann D., Minowada J., Gallo R. C.: Isolation and transmission of human retrovirus (human T-cell leukemia virus). Science 219: 856-859, 1983.
Popovic M., Reitz M. S., Jr., Sarngadharan M. G., Robert-Guroff M., Kalyanaraman V. S., Nakao Y., Mioshi I., Minowada J., Yoshida M., Ito Y., Gallo R. C.: The virus of Japanese adult T-cell leukemia is a member of the human T-cell leukemia virus group. Nature 300, 63-66, 1982.
Svoboda J., Popovic M., Steinerova H., Mach O., Shoyab M., Baluda M. A.: Incomplete viral genome in non-virgenic mouse tumor cell line, RVP₃, transformed by Prague strain of avian sarcoma virus. Int. J. Cancer 19, 851-856, 1977.
Popovic M., Svoboda J., Suni J., Vaheri A., Ponten J.: Expression of viral protein p27 in avian sarcoma virus-transformed mammalian cells and helper-de-pendent rescue of Rous sarcoma virus. Int. J. Cancer 19, 851-856, 1977.

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