Vojtěšek Bořivoj

RNDr., DrSc.
Born October 25, 1960

• Molecular oncology
• Member of Learned Society since 2003

Educational and professional preparation:

• 1976-1979, graduate, academic secondary school, Břeclav;
• 1979-1984, Faculty of Natural Science, Department of Molecular Biology, Jan Evangelista Purkyně University, Brno;
• 1985, RNDr.; 1990 CSc.;
• 1996, DrSc., scientific field of oncology, Academy of Sciences of Czech Republic (AC CR), Prague and Slovak Academy of Sciences Bratislava.

Employment and academic positions:

• 1985-present, Masaryk Memorial Cancer Institute (MMCI), Brno (formerly the Research Institute of Clinical and Experimental Oncology);
• 1985-1999, principal scientist, MMCI;
• 1999-2000, Head, Department of Cellular and Molecular Oncology, MMCI;
• 2001-present, Head, working group, Biology of Tumours and Proteomics, MMCI

Membership in selected domestic scientific bodies:

• 1993-present, member, Scientific Council, MMCI
• 1999-2002, member, Scientific Council, Second Faculty of Medicine, Charles University (FM CU), Prague
• 2003-present, member, Scientific Council, Faculty of Science, Palacký University, Olomouc
• 2003-present, member, Scientific Council of Biophysical Institute, AS CR, Brno
• 2003-present, member, Scientific Council, Institute of Animal Physiology, AS CR, Liběchov

Membership and positions in international organizations and societies:

• Member, European Association for Cancer Research (EACR)

Notable awards:

• 1996, Award, Minister of Health, Ministry of Health
• 1999, Award, Minister of Health, Ministry of Health
• 2001, Award, Minister of Health, Ministry of Health
• 2003, Award, Minister of Health, Ministry of Health

Selected publications:

• B. Vojtesek, J. Bartek, C. A. Midgley, D. P. Lane: An immunochemical analysis of human p53: New monoclonal antibodies and epitope mapping using recombinant p53. J. Immunol. Methods 151, 237-244 (1992)
• B. Vojtesek, D. P. Lane: Regulation of p53 protein expression in human breast cancer cell lines. J. Cell Science 105, 607-612 (1993)
• B. Vojtesek, C. J. Fisher, D. M. Barnes, D. P. Lane: Comparison between p53 staining in tissue sections and p53 proteins levels measured by an ELISA technique. Br. J. Cancer 67, 1254-1258 (1993)
• K. H. Vousden, B. Vojtesek, CH. Fisher, D. P. Lane: HPV-16E7 or adenovirus E1A can overcome the growth arrest of cells immortalized with a temperature-sensitive p53. Oncogene 8, 1697-1702 (1993)
• B. Vojtesek, H. Dolezalova, L. Lauerova, M. Svitakova, P. Havliš, J. Kovarik, C. A. Midgley, D. P. Lane: Conformational changes in p53 analysed using new antibodies to the core DNA binding domain of the protein. Oncogene 10, 389-393 (1995)
• D. Niewolik, B. Vojtesek, J. Kovarik: p53 derived from human tumour cell lines and containing distinct point mutations can be activated to bind its consensus target sequence. Oncogene 10 , 881-890 (1995)
• V. Kotala, S. Uldrijan, M. Horký, M. Trbůšek, M. Strnad, B. Vojtěšek: Potent induction of wild-type p53-dependent transcription in tumour cells by a synthetic inhibitor of cyclin-dependent kinases. Cell. Mol. Life. Sci. 9, 1333-13339 (2001)
• R. Nenutil, P. Ceskova, P. J. Coates, K. Nylander, B. Vojtesek: Differential Expression of p73alpha in Normal Ectocervical Epithelium, Cervical Intraepithelial Neoplasia, and Invasive Squamous Cell Carcinoma. Int. J. Gynecol Pathol. 22(4), 386-392 (2003)
• M.A. Sheard, S. Uldrijan, B. Vojtesek.: Role of p53 in regulating constitutive and X-radiation-inducible CD95 expression and function in carcinoma cells. Cancer Res. 63(21), 7176-7184 (2003)
• S. Pospisilova, V. Brazda, K. Kucharikova, M.G. Luciani, T.R. Hupp, P. Skladal, E. Palecek, B. Vojtesek: Activation of the DNA-binding ability of latent p53 protein by protein kinase C is abolished by protein kinase CK2. Biochem J. 378 (Pt 3), 939-947 (2004)